Academic Events » Symposium

1SDP Phase Separation by Biopolymers: Basics and Applications

Wed. Sep 28, 2022 1:50 PM - 4:20 PM Room D (Multi-purpose room A)

Organizers:Ryo Kitahara(Ritsumeikan Univ.),Tomoshi Kameda(AIST)

Although cells organize many biochemical processes in membrane-less compartments via liquid-liquid phase separation (LLPS), physicochemical properties and molecular details of LLPS consisting of proteins and nucleic acids are still largely unknown. This symposium contains lectures on the physicochemical basis of biomolecular LLPS and some recent experimental and theoretical developments to elucidate its structure and dynamics. For example, pressure perturbation spectroscopy, single-molecule fluorescence microscopy, Raman microscopy, and molecular dynamics simulations for protein LLPS will be introduced.

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1:50 PM - 1:55 PM

[1SDP-00] Opening Remarks

1:55 PM - 2:23 PM

[1SDP-1] Pressure-jump kinetics of liquid-liquid phase separation (LLPS) : The RNA-binding protein fused in sarcoma (FUS)

〇Ryo Kitahara^1,2, Shujie Li², Takuya Yoshizawa³ (1.Coll. Pharm. Sci., Ritsumeikan Univ., 2.Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 3.Coll. Life Sci., Ritsumeikan Univ.)

2:23 PM - 2:51 PM

[1SDP-2] Liquid-liquid phase separation of proteins based on the solubility of amino acids

〇Akira Nomoto¹, Kentaro Shiraki¹ (1.Pure and Appl. Sci., Univ. Tsukuba)

2:51 PM - 3:19 PM

[1SDP-3] Raman and Brillouin microscopy as a tool for quantitative study of LLPS

〇Shinji Kajimoto^1,2 (1.Grad. Sch. Pharm. Sci., Tohoku University, 2.JST PRESTO)

3:19 PM - 3:47 PM

[1SDP-4] Molecular grammar characterization of recruitment and translational dynamics of guest proteins in liquid droplets

〇Kiyoto Kamagata¹ (1.IMRAM, Tohoku Univ.)

3:47 PM - 4:15 PM

[1SDP-5] Prediction of peptide aggregation by combining molecular dynamics simulation and machine learning

〇Tomoshi Kameda¹ (1.AIRC, AIST)

4:15 PM - 4:20 PM

Session information