The 60th Annual Meeting of BSJ

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Academic Events » Symposium

2SDP Metal-ion regulation of enzyme dynamics

Thu. Sep 29, 2022 1:50 PM - 4:20 PM Room D (Multi-purpose room A)

Organizers:Masayuki Oda(Kyoto Prefectural Univ.),Kosuke Morikawa(Kyoto Univ.)

Enzyme function closely correlates with its structural dynamics, and is often regulated by metal-ion binding. In many cases, metal-ions bind to enzymes rather weakly, and induce protein conformations or conformational ensembles. This essential structure-function relationship is an attractive but difficult target to be analyzed. The invited speakers present challenging efforts on enzymes, such as cutinase, RNaseH, and DNAzyme, which are regulated by Ca2+ or Mg2+. We hope that discussions based on presented biophysical data could facilitate us to understand real dynamic views of metal-enzyme interactions.