Thu. Sep 29, 2022 8:45 AM - 11:15 AM Room E (Multi-purpose room B)

Organizers:Akihiro Narita(Nagoya Univ.),Shuji Akiyama(IMS)

Is it possible to explain biological phenomena occurring at the cellular level on the basis of the physicochemical properties of molecules? Observations focused on the cellular scale provide little information about molecules, while investigations of molecular structure and dynamics with high spatiotemporal resolution require handling isolated and purified samples in vitro. However, how and what kind of connections do we need in order to understand biological phenomena? In modern life science research, the initial selection of the most suitable model organism has a great impact on the success or failure of later research. In the same way, the selection of an appropriate spatiotemporal scale is important for cutting into the logic of "cross-scale causality". From this perspective, we realize that the smallest unit of the molecular system that shows some correlation with physiological properties at the tissue or cellular level is exclusively concentrated in the 100 nm scale (or several hundred molecules). In this symposium, we will examine the spatiotemporal hierarchy of the 100 nm scale from multiple perspectives of biophysics, structural biology, and computational science, and discuss strategies for the evolution of correlation into causation.