Academic Events » Symposium

3SFA Unexpected dynamic mechanisms of life uncovered by Cryo-EM

Fri. Sep 30, 2022 9:00 AM - 11:30 AM Room F (Hakodate Citizen Hall Mian HallA)

Organizers:Osamu Nureki(The Univ. of Tokyo),Hiroshi Nishimasu(The Univ. of Tokyo)

Recent outstanding development of single particle analysis of cryo-EM allows high-resolution structure determinations of huge and flexible supramolecular complexes, which have been never available. In this symposium, we will present and discuss on current topics of unexpected dynamic molecular and cellular mechanisms of protein and nucleic acid supramolecular complexes involved in various life phenomena.

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9:00 AM - 9:30 AM

[3SFA-1] Structure-function relationship of pump-like cation channelrhodopsins

Koichiro Kishhi¹, Yoon Seok Kim², Masahiro Fukuda¹, Masatoshi Inoue², Tsukasa Kusakizako³, Peter Wang², Toshiki Matsui¹, Yamashita⁴, Takashi Nagata⁵, Masae Konno⁵, Tomoko Uemura⁶, Kehong Liu⁶, Mikihiko Shibata⁷, Norimichi Nomura⁶, So Iwata⁶, Osamu Nureki³, Keiichi Inoue⁴, Karl Deisseroth², 〇Hideaki Kato¹ (1.Komaba Inst. Sci., Grad. Sch. Arts. Sci., Univ. Tokyo, 2.Stanford Univ., 3.Grad. Sch. Sci., Univ. Tokyo, 4.MRC, 5.ISSP, Univ. Tokyo, 6.Grad. Sch. Med., Kyoto Univ., 7.Kanazawa Univ.)

9:30 AM - 10:00 AM

[3SFA-2] Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex

〇Hiroshi Nishimasu¹ (1.The University of Tokyo)

10:00 AM - 10:20 AM

[3SFA-3] High-resolution Cryo-EM analysis reveals the mechanism of binary toxin translocation

〇Tomohito Yamada¹, Yukihiko Sugita^2,3, Takeshi Noda², Hideaki Tsuge¹ (1.Graduate School of Life Science, Kyoto Sangyo University, 2.Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University, 3.Hakubi Center for Advanced Research, Kyoto University)

10:20 AM - 10:40 AM

[3SFA-4] Structure of the IscB-ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9

〇Kazuki Kato¹, Sae Okazaki¹, Soumya Kannan², Feng Zhang², Hiroshi Nishimasu¹ (1.RCAST, Univ. Tokyo, 2.MIBR, MIT)

10:40 AM - 11:00 AM

[3SFA-5] Structural analysis of the late assembly states of mitochondorial ribosome to the translation initiation

〇Yuzuru Itoh^1,2, Anas Khawaja³, Joanna Rorbach³, Alexey Amunts² (1.Dept. BioSci., Grad. Sch. Sci., Univ. Tokyo, 2.SciLifeLab, DBB, Stockholm University, 3.Karolinska Institutet)

11:00 AM - 11:30 AM

[3SFA-6] Structural basis for molecular mechanisms of membrane proteins and non-coding RNA

〇Osamu Nureki¹ (1.Grad. Sch. Sci., Univ. Tokyo)