The 61st Annual Meeting of the Biophysical Society of Japan

Session information

Academic Events » Symposium

3SBA Biophysical approaches against the drug target proteins involving intrinsically disordered regions

Thu. Nov 16, 2023 9:00 AM - 11:30 AM Room B (Exhibition Room 212 (Bldg. 2, 1F))

Organizers: Hiroaki Hidekazu (Nagoya Univ.)、Shirai Tsuyoshi (Nagahama Inst. of Bio-Science and Tech.)

Recent progress in proteomics of human diseases and host-pathogen interactions has revealed that potential therapeutic targets contain intrinsically disordered regions (IDRs). Proteins with large amounts of IDRs often lack a fixed or ordered three-dimensional structure, rendering them unsuitable for the modern structure-guided drug discovery methodology. This symposium aims to explore different biophysical approaches to drug discovery and development against IDRs. We will focus on methods that go beyond the classical lock-and-key model, including innovative approaches to understand the structural and dynamic properties of IDRs.

9:55 AM - 10:20 AM

〇Akihito Nishiyama1, Masahiro Shimizu2,3, Noriyuki Kodera2, Yuriko Ozeki1, Kouta Mayanagi4, Takehiro Yamaguchi5, Sohkichi Matsumoto1 (1.Dept. Bacteriol., Niigata Univ. Sch. Med., 2.NanoLSI, Kanazawa Univ., 3.Div. Quantum Beam Mater. Sci., Inst. Integr. Radiat. Nuc. Sci., Kyoto Univ, 4.Med. Inst. Bioregulation, Kyushu Univ., 5.Dept. Pharmacol, Osaka Metro Univ. Med. Sch.)