Kiyoshi Egawa¹, Yoshihiro Hirata¹, Mitsuru Ishikawa⁴, Hideaki Siraishi¹, Shinji Saito², Yukitoshi Takahasi³, Hironobu Okuno⁴, Hideyuki Okano⁴ (1.Department of Pediatrics, Hokkaido University Graduate school of Medicine, Japan, 2.Department of Neonatology and Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Japan, 3.Department of Pediatrics, National Epilepsy Center, Shizuoka Institute Epilepsy and Neurological Disorders, Japan, 4.Department of Physiology, Keio University Graduate school of Medicine, Japan)

Takashi Maeda¹, Hiroyuki Kidokoro², Takashi Tachibana¹, Tomohiko Nakata², Hiroyuki Yamamoto², Tetsuo Kubota³, Toru Kato⁴, Akihisa Okumura⁵, Jun Natsume^2,6, Masahiro Hayakawa⁷ (1.Department of Pediatrics Cardiology and Neonatology, Ogaki Municipal Hospital, Japan, 2.Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan, 3.Department of Pediatrics, Anjo Kosei Hospital, Japan, 4.Department of Pediatrics, Okazaki City Hospital, Japan, 5.Department of Pediatrics, Aichi Medical University, Japan, 6.Department of Developmental Disability Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan, 7.Department of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Japan)

Reiko Koichihara, Shin-ichiro Hamano, Hazuki Nonoyama, Atsuro Daida, Satoru Ikemoto, Yuko Hirata, Ryuki Matsuura (Neurology, Saitama Children's Medical Center, Japan)

Yu Okai^1,2, Yuji Ito^1,2, Satoshi Maesawa², Epifanio Bagarinao², Masaharu Tanaka¹, Yoko Sakaguchi¹, Hiroyuki Yamamoto^1,2, Tomohiko Nakata¹, Hiroyuki Kidokoro¹, Jun Natsume^1,3 (1.Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2.Brain and Mind Research Center, Nagoya University, Nagoya, Japan, 3.Department of Developmental Disability Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan)

Yuki Maki¹, Hiroyuki Kidokoro¹, Akihisa Okumura², Hiroyuki Yamamoto¹, Tomohiko Nakata¹, Tatsuya Fukasawa³, Tetsuo Kubota³, Tamiko Negoro¹, Kazuyoshi Watanabe¹, Jun Natsume^1,4 (1.Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan, 2.Department of Pediatrics, Aichi Medical University, Japan, 3.Department of Pediatrics, Anjo Kosei Hospital, Japan, 4.Department of Developmental Disability Medicine, Nagoya University Graduate School of Medicine, Japan)

Hiroyuki Kidokoro¹, Hiroyuki Yamamoto¹, Tomohiko Nakata¹, Tatsuya Fukasawa², Tetsuo Kubota², Toru Kato³, Akihisa Okumura⁴, Masahiro Hayakawa¹, Jun Natsume¹ (1.Nagoya University, Japan, 2.Anjo Kosei Hospital, Japan, 3.Okazaki City Hospital, Japan, 4.Aichi Medical University, Japan)

Ayana Hirose, Jun Shibasaki, Moyoko Tomiyasu, Tatsuro Kumaki, Yu Tsuyusaki, Tomohide Goto, Noriko Aida (Kanagawa Children's Medical Center, Japan)

Satoru Ikemoto^1,2, Shin-ichiro Hamano^1,2, Atsuro Daida², Yuko Hirata², Ryuki Matsuura², Reiko Koichihara¹, Hazuki Nonoyama² (1.Department for Child Health and Human Development, Saitama Childrens Medial Center, Japan, 2.Division of Neurology, Saitama Childrens Medical Center, Japan)

Yuko Hirata, Shin-ichiro Hamano, Reiko Koichihara, Ryuki Matsuura, Satoru Ikemoto, Atsuro Dada, Hazuki Nonoyama (Division of Neurology, Saitama Children's Medical Center, Japan)

nanako hamada¹, Koh-ichi Nagata¹, Shunsuke Ogaya², Mitsuko Nakashima³, Hirotomo Saitsu⁴, Mitsuhiro Kato⁵, Naomichi Matsumoto³, Yuji Sugawara⁶, Shimpei Baba⁸, Kentaro Shirai⁷ (1.Department of Molecular Neurobiology, Institute for Developmental Research, Japan, 2.Department of Pediatric Neurology, Central Hospital, Aichi Human Service Center, Japan, 3.Department of Human Genetics, Yokohama City University Graduate School of Medicine, Japan, 4.Department of Biochemistry, Hamamatsu University School of Medicine, Japan, 5.epartment of Pediatrics, Showa University School of Medicine, Japan, 6.Department of Pediatrics, Soka Municipal Hospital, Japan, 7.Department of Pediatrics, Tsuchiura Kyodo Hospital, Japan, 8.Department of Child Neurology, Comprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, Japan)

Nodoka Hinokuma¹, Kazuyuki Nakamura², Shinjiro Akaboshi³, Mitsuko Nakashima^4,5, Hirotomo Saitsu^4,5, Naomichi Matsumoto⁵, Mitsuhiro Kato^1,2 (1.Department of Pediatrics, Showa University School of Medicine, Japan, 2.Department of Pediatrics, Yamagata University Faculty of Medicine, Japan, 3.Department of Pediatrics, Tottori Medical Center, Japan, 4.Department of Biochemistry, Hamamatsu University School of Medicine, Japan, 5.Department of Human Genetics, Yokohama City University Graduate School of Medicine, Japan)

Shinichiro Morichi¹, Kanako Kanou¹, Tomoko Takamatsu¹, uu oo¹, Mika takeshita¹, Yu Ishida¹, Shingo Oana¹, Gaku Yamanaka¹, Mitsuhiro Kato², Hisashi Kawashima¹ (1.Department of Pediatrics, Tokyo Medical University, Japan, 2.Department of Pediatrics, Showa University, Japan)

Soo Yeon Kim¹, Young Kyu Shim¹, Woo Joong Kim¹, Young Jun Ko¹, Hunmin Kim², Hee Hwang², Ji Eun Choi³, Byung Chan Lim¹, Jong-Hee Chae¹, Ki Joong Kim¹ (1.Seoul National University Children's Hospital, Korea, 2.Seoul National University Bundang Hospital, Korea, 3.Seoul National University Boramae Medical Center, Korea)

Toshimichi Fukao^1,2, Fumikazu Sano¹, Atsushi Naito², Hideaki Kanemura¹, Masao Aihara³ (1.Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Japan, 2.Department of Neonatology, Perinatal Medical Center, Yamanashi Prefectural Central Hospital, Japan, 3.Graduate Faculty of Interdisciplinary Research, Graduate School, University of Yamanashi, Japan)

taira toki¹, Yuko Shimizu-Motohashi¹, Noriko Sumitomo¹, Eri Takeshita¹, Akihiko Ishiyama¹, Takashi Saito¹, Kenji Sugai^1,2, Hirofumi Komaki¹, Eiji Nakagawa¹, Masayuki Sasaki¹ (1.Department of Child Neurology National Center Hospital, National Center of Neurology and Psychiatry, Japan, 2.Marianna University School of Medicine, Kanagawa, Epilepsy Center, Japan)

Shohei Kusabiraki¹, Takaharu Nishijima¹, Tomomi Tanaka¹, Kentaro Tamura², Taketoshi Yoshida², Yuichi Adachi¹, Mitsuhiro Kato³, Shoko Miyamoto⁴, Mitsuko Nakashima⁴, Hirotomo Saitsu⁴ (1.Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan, 2.Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital, Toyama, Japan, 3.Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan, 4.Biochemistry Department, Hamamatsu University School of Medicine, Hamamatsu, Japan)

Yu Min Syu, Jao-Shwann Liang (Far Eastern Memorial Hospital, Taipei, Taiwan)

Ryosuke Urabe¹, Yuichi Abe¹, Rika Kosaki², Eriko Koshimizu³, Satoko Miyatake³, Naomichi Matsumoto³, Mitsuhiro Kato⁴, Masaya Kubota¹ (1.Division of Neurology, National Center for Child Health and Development, Japan, 2.Division of Medical Genetics, National Center for Child Health and Development, Japan, 3.Department of Human Genetics, Yokohama City University Graduate School of Medicine, Japan, 4.Department of Pediatrics, Showa University School of Medicine, Japan)

Konomi Shimoda¹, Takayuki Mori¹, Yu Kakimoto¹, Satoshi Takenaka¹, Atsushi Satou¹, Akira Oka¹, Masashi Mizuguchi² (1.The Department of Pediatrics, University of Tokyo, Japan, 2.Department of Developmental Medical Sciences, The University of Tokyo, Tokyo, Japan)

Taikan Oboshi, Shodou Hirano, Ken Nakajima, Tomokazu Kimizu, Tae Ikeda, Yukiko Mogami, Keiko Yanagihara, Yasuhiro Suzuki (Osaka Prefectural Hospital Organization Osaka Women's and Children's Hospital, Japan)

Kaori Sassa^1,2, Masato Arao¹, Sayaka Ajihara¹, Mizuki Nonomiya¹, Masaki Matsuzaki¹, Akira Ohtake^1,3, Hideo Yamanouchi^1,2 (1.Department of Pediatrics, Saitama Medical University Hopital, Japan, 2.Comprehensive Epilepsy Center, Saitama Medical University Hopital, Japan, 3.Center for Intractable Diseases, Saitama Medical University Hopital, Japan)

Ayana Sunaga¹, Kenji Fujita¹, Norikatsu Hikita¹, Satoru Sakuma¹, Takashi Hamazaki¹, Toshiyuki Yamamoto², Toshiyuki Seto¹ (1.Department of Pediatrics, Osaka City University Graduate School of Medicine, Japan, 2.Institute of Clinical Genomics, Tokyo Women's Medical University, Japan)

Takuya Hayashida, Tatsuharu Sato, Nanako Nishiguchi, Hiroyuki Moriuchi (Department of Pediatrics, Nagasaki University Hospital, Japan)

Takako Fujita¹, Yukiko Ihara¹, Hiromi Yamaguchi¹, Hitomi Hayashi¹, Atsushi Ishii¹, Hiroshi Ideguchi¹, Takahito Inoue¹, Sawa Yasumoto², Shinichi Hirose¹ (1.Department of Pediatrics, School of Medicine, Fukuoka University, Japan, 2.Center of medical education, School of medicine. Fukuoka University, Japan)

Takahiro Abiko, Kazuyuki Nakamura, Ayako Sasaki, Tetsuo Mitsui (Department of Pediatrics, Faculty of Medicine, Yamagata University, Japan)

Meltem Uzun¹, Elif Acar Arslan², Tahsin Yakut³ (1.Private Dr.Meltem Uzun Pediatric Neurology Clinics, Turkey, 2.Division of Pediatric Neurology, Medical Faculty of Karadeniz Technical University, Turkey, 3.Division of Medical Genetics, Jimer Hospital, Turkey)

Satoshi Akamine¹, Pin Chong Fee¹, Fumiya Yamashita¹, Kenichi Maeda¹, Toshiyuki Yamamoto², Ryutaro Kira¹ (1.Department of Pediatric Neurology, Fukuoka Children's Hospital, Fukuoka, Japan, 2.Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Tokyo, Japan)

Kozue Kuwabara¹, Masanori Ito², Takahiro Motoki³, Mitsumasa Fukuda⁴ (1.Ehime Prefectural Central Hospital, Japan, 2.Yawatahama City General Hospital, Japan, 3.Ehime University Graduate School of Medicine, Japan, 4.Tokyo Metropolitan Neurological Hospital, Japan)

Pin Fee Chong, Fumiya Yamashita, Kenichi Maeda, Satoshi Maeda, Ryutaro Kira (Department of Pediatric Neurology, Fukuoka Children's Hospital, Japan)

Atsuro Daida^1,2, Shin-ichiro Hamano¹, Hazuki Nonoyama¹, Satoru Ikemoto³, Yuko Hirata¹, Ryuki Matsuura¹, Reiko Koichihara³, Gaku Yamanaka² (1.Division of Neurology, Saitama Children's Medical Center, Japan, 2.Division of Pediatrics, Tokyo Medical University, Japan, 3.Department for Child Health and Human Development, Saitama Children's Medical Center, Japan)

Hironao Shirai, Yutaka Nonoda, Toshiyuki Iwasaki (Kitasato University Hospital Department of pediatrics, Japan)

LEECHIN WONG¹, WANG-TSO LEE² (1.Cathay general hospital, Taiwan, 2.National Taiwan University Children Hospital, Taiwan)

Feng-Chin Lee (Tri-Service general Hospital, Taiwan)

Sho Narahara¹, Tatsuya Fukasawa¹, Tetsuo Kubota¹, Tamiko Negoro¹, Hideyuki Asai², Mitsuhiro Kato² (1.Anjo Kosei Hospital, Department of Pediatrics, Japan, 2.Showa University, Department of Pediatrics, Japan)

REI TAKADA^1,2, Takenori Tozawa¹, Hidehito Kondo², Zenro Kizaki², Chie Harasima³, Kei Murayama⁴, Akira Ohtake⁵, Tomohiro Chiyonobu² (1.Department of Pediatrics, Japanese Red Cross Society Kyoto Daiichi Hospital, Kyoto, Japan, 2.Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan, 3.Department of Pediatrics, The Japan Baptist Hospital, Kyoto, Japan, 4.Department of Metabolism, Chiba Children's Hospital, Chiba, Japan, 5.Department of Pediatrics, Saitama Medical University Hospital, Irima, Japan)

Rie Miyata¹, Mitsuhiro Kato², Tsuyoshi Mizuguchi³, Naomichi Matsumoto³ (1.Tokyo-Kita Medical Center, Japan, 2.Showa University, Japan, 3.Yokohama City University, Japan)

Syuan-Yu Hong (Division of Pediatrics Neurology, Taiwan)

Kazuhiko Hashimoto¹, Tatsuharu Sato¹, Takuya Hayashida¹, Nanako Nishiguchi¹, Toshiyuki Sakai³, Satoko Miyatake³, Hiroyuki Moriuchi¹, Naomichi Matsumoto³, Mitsuhiro Kato² (1.Department of Pediatrics, Nagasaki University Hospital, Japan, 2.Department of Pediatrics, Showa University School of Medicine, Japan, 3.Department of Human Genetics, Yokohama City University Graduate School of Medicine, Japan)

Yuki Shimizu¹, Yuri Dowa¹, Takashi Shiihara¹, Mio Watanabe¹, Eriko Suzuki¹, Hideyuki Asai², Nodoka Hinokuma², Mitsuhiro Kato² (1.Department of Neurology Gunma Children's Medical Center, Japan, 2.Department of Pediatrics Showa University School of Medicine, Japan)

Nahoko Ueda K¹, Yuichi Abe¹, Ryosuke Urabe¹, Michiko Kawai¹, Sato Suzuki-Muromoto¹, Go Takei¹, Itaru Hayakawa¹, Masaya Kubota¹, Mitsuhiro Kato² (1.Division of Neurology, National Center for Child Health and Development, Japan, 2.Department of Pediatrics, Showa University School of Medicine, Japan)

Tohru Okanishi¹, Ayataka Fujimoto², Shimpei Baba¹, Shinji Itamura¹, Naoki Ichikawa², Sotaro Kanai^1,3, Horotaka Motoi^1,4, Hideo Enoki¹ (1.Department of Child Neurology, Seirei-Hamamatsu General Hospital, 2-12-12, Sumiyoshi, Hamamatsu, Shizuoka 434-8558, Japan, 2.Comprehensive Epilepsy Center, Seirei-Hamamatsu General Hospital, 2-12-12, Sumiyoshi, Hamamatsu, Shizuoka 434-8558, Japan, 3.Division of Child Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, Tottori 683-8504, Japan, 4.Departments of Pediatrics and Neurology, Children's Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA.)

Yuki Hyodo¹, Naoko Matsuda¹, Kiyohiro Kim¹, Takashi Shibata¹, Mari Akiyama¹, Tatsuya Sasaki², Tomoyuki Akiyama¹, Katsuhiro Kobayashi¹ (1.Department of Child Neurology, Okayama University Hospital, Japan, 2.Department of Neurological Surgery, Okayama University Hospital, Japan)

Hirofumi Kurata^1,2,3, Kengo Saito¹, Fumiaki Kawashima¹, Takuya Ikenari¹, Masayoshi Oguri^1,4, Yoshiaki Saito², Yoshihiro Maegaki², Tetsuji Mori¹ (1.Department of Biological Regulation, School of Health Science, Faculty of Medicine, Tottori University, Yonago, Japan, 2.Division of Child Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Japan, 3.Department of Pediatrics, National Hospital Organization, Kumamoto Saishunso National Hospital, Koshi, Japan, 4.Department of Pathobiological Science and Technology, Faculty of Medicine, Tottori University, Yonago, Japan)

Shota Akiyama¹, Masayoshi Oguri¹, Masashi Nishiyama², Yuka Matsuura¹, Yoshiaki Saito³, Yoshio Iwai², Yasuaki Hirooka¹, Yoshihiro Maegaki³ (1.Department of Pathological Science and Technology, School of Life Sciences, Tottori University Faculty of Medicine, Yonago, Japan, 2.Graduate School of Engineering, Tottori, Japan, 3.Division of Child Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Japan)

Kenichi Maeda¹, Pin Chong Fee¹, Fumio Yamashita¹, Sooyoung Lee², Ryutaro Kira¹ (1.Department of Pediatric Neurology, Fukuoka Children's Hospital, Japan, 2.Department of Intensive Care Unit, Fukuoka Children's Hospital, Japan)

Mariko Kasai^1,2, Akiko Shibata^1,2, Ai Hoshino¹, Akira Oka², Masashi Mizuguchi¹ (1.Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Japan, 2.Department of Pediatrics, The University of Tokyo Hospital, Japan)

Ko Hirata^1,2, Yuji Sugawara¹, Sayaka Takeda¹, Ai Hoshino^3,4, Satoko Kumada³, Takeshi Hasegawa¹ (1.Department of Pediatrics, Soka Municipal Hospital, Soka, Japan, 2.Department of Pediatrics, Tsuchiura Kyodo Hospital, Ibaraki, Japan, 3.Department of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan, 4.Department of Developmental Medical Sciences, Graduate School of Medicine, University of Tokyo, Tokyo, Japan)

Akiko Shibata^1,2, Mariko Kasai^1,2, Ai Hoshino¹, Taku Miyagawa^3,4, Atsushi Ishii⁵, Shinichi Hirose⁵, Akira Oka², Masashi Mizuguchi¹ (1.Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Japan, 2.Department of Pediatrics, The University of Tokyo, Japan, 3.Sleep Disorders Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Japan, 4.Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Japan, 5.Department of Pediatrics, Fukuoka University, Japan)

YU WENHAO (Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan)

Kazuna Yamamoto, Hideki Hoshino, Mei Haruyama, Kotaro Mieno, Yoshiaki Shibuya, Yasuhiro Sato, Marie Nakai, Masakazu Mimaki (Teikyo University, Japan)

Cheng Yen Kuo, Jainn-Jim Lin, I-Jun Chou, Min-Liang Chou, Po-Cheng Hung, Yi-Shan Wang, Huei-Shyong Wang, Kuang-Lin Lin (Division of Pediatric Neurology, Chang Gung Children Hospital and Chang Gung Memorial Hospital, Taoyuan, Taiwan)

Kenjiro Kikuchi^1,2, Shin-ichiro Hamano² (1.Department of Pediatrics, The Jikei University School of Medicine, Japan, 2.Division of Neurology, Saitama Children's Medical Center, Japan)

Li-Wen Chen¹, Ching-Chuan Liu¹, Shih-Min Wang¹, Yi-Shan Tsai², Jen-Ren Wang³ (1.Department of Pediatrics, National Cheng Kung University Hospital, Taiwan, 2.Department of Medical Imaging, National Cheng Kung University Hospital, Taiwan, 3.Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Taiwan)

Mir Anwar (Richmond Chest Hospital, South Africa)