[L-14] Neurophysiological aspects of neonatal seizures
Irish Centre for Fetal and Neonatal Translational Research (INFANT) & Department of Paediatrics & Child Health, University College Cork, Cork, IRELAND.
ORCID ID: https://orcid.org/0000-0003-0920-5291 Email: g.boylan@ucc.ie
EDUCATION AND PROFESSIONAL QUALIFICATIONS:
2008 - MA (Education), UCC.
2002 - PhD in Clinical Medicine, University of London.
1991 - MSc (Comparative Physiology), University of London.
1989 - BSc (Physiology), University of London.
CURRENT POSITION:
April 2013 – 2017: Director, INFANT Research Centre, University College Cork, IRELAND
June 2009 – Present: Professor of Neonatal Physiology, Department of Paediatrics and Child Health, University College Cork.
SELECTED PUBLICATIONS: Full publication list available at https://orcid.org/0000-0003-0920-5291
Rennie JM, de Vries LS, Blennow M, Foran A, Shah DK, Livingstone V, van Huffelen AC, Mathieson SR, Pavlidis E, Weeke LC, Toet MC, Finder M, Pinnamaneni RM, Murray DM, Ryan AC, Marnane WP, Boylan GB. Characterisation of neonatal seizures and their treatment using continuous EEG monitoring: a multicentre experience. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 24. pii: fetalneonatal-2018-315624.
O'Sullivan MP, Looney AM, Moloney GM, Finder M, Hallberg B, Clarke G, Boylan GB, Murray DM. Validation of Altered Umbilical Cord Blood MicroRNA Expression in Neonatal Hypoxic-Ischemic Encephalopathy. JAMA Neurol. 2018 Dec 28. doi: 10.1001/jamaneurol.2018.4182.
Soul JS, Pressler R, Allen M, Boylan G, Rabe H, Portman R, Hardy P, Zohar S, Romero K, Tseng B, Bhatt-Mehta V, Hahn C, Denne S, Auvin S, Vinks A, Lantos J, Marlow N, Davis JM; International Neonatal Consortium. Recommendations for the design of therapeutic trials for neonatal seizures. Pediatr Res. 2018 Dec 24. doi: 10.1038/s41390-018-0242-2.
Dempsey EM, Kooi EMW, Boylan G. It's All About the Brain-Neuromonitoring During Newborn Transition. Semin Pediatr Neurol. 2018 Dec;28:48-59. doi: 10.1016/j.spen.2018.05.006.
Finn D, O'Toole JM, Dempsey EM, Boylan GB. EEG for the assessment of neurological function in newborn infants immediately after birth. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 26. pii: fetalneonatal-2018-315231.
O’Shea A, Lightbody G, Boylan G, Temko A. Investigating the Impact of CNN Depth on Neonatal Seizure Detection Performance. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:5862-5865.
Goulding, R. M., Stevenson, N. J., Murray, D. M., Livingstone, V., Filan, P. M., & Boylan, G. B. (2017). Heart rate variability in hypoxic ischemic encephalopathy during therapeutic hypothermia. Pediatr Res. 81(4):609-615.
Ahmed, R., Temko, A., Marnane, W., Lightbody, G., & Boylan, G. (2016). Grading hypoxic–ischemic encephalopathy severity in neonatal EEG using GMM supervectors and the support vector machine. Clinical Neurophysiology, 127(1), 297-309.
Lloyd, R. O., O’Toole, J. M., Livingstone, V., Hutch, W. D., Pavlidis, E., Cronin, A. M., & Boylan, G. B. (2016). Predicting 2-y outcome in preterm infants using early multimodal physiological monitoring. Pediatr Res. 80(3):382-8.
Mathieson, S. R., Stevenson, N. J., Low, E., Marnane, W. P., Rennie, J. M., Temko, A., Lightbody, G., & Boylan, G. B. (2016). Validation of an automated seizure detection algorithm for term
neonates. Clinical Neurophysiology 127(1), 156-168.
Murray, D. M., O’Connor, C. M., Ryan, C. A., Korotchikova, I., & Boylan, G. B. (2016). Early EEG Grade and Outcome at 5 Years After Mild Neonatal Hypoxic Ischemic Encephalopathy. Pediatrics 138(4) Pressler R, Boylan GB, Marlow N et al. (2015). Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurol. 14(5):469-77.
Stevenson NJ, Clancy RR, Vanhatalo S, Rosén I, Rennie JM, Boylan GB. (2015). Interobserver agreement for neonatal seizure detection using multichannel EEG. Ann Clin Transl
Neurol.1;2(11):1002-11.
An Automated System for Grading EEG Abnormality in Term Neonates with Hypoxic-Ischaemic Encephalopathy N. J. Stevenson, I. Korotchikova, A. Temko, G. Lightbody, W. P. Marnane, G. B. Boylan. (2013). Annals of Biomedical Engineering. Volume 41, Issue 4, pp 775-785.
Temko A, Thomas E, Marnane W, Lightbody G, Boylan GB. (2011). Performance assessment for EEG-based neonatal seizure detectors. Clin Neurophysiol. 122(3):474-82.
ORCID ID: https://orcid.org/0000-0003-0920-5291 Email: g.boylan@ucc.ie
EDUCATION AND PROFESSIONAL QUALIFICATIONS:
2008 - MA (Education), UCC.
2002 - PhD in Clinical Medicine, University of London.
1991 - MSc (Comparative Physiology), University of London.
1989 - BSc (Physiology), University of London.
CURRENT POSITION:
April 2013 – 2017: Director, INFANT Research Centre, University College Cork, IRELAND
June 2009 – Present: Professor of Neonatal Physiology, Department of Paediatrics and Child Health, University College Cork.
SELECTED PUBLICATIONS: Full publication list available at https://orcid.org/0000-0003-0920-5291
Rennie JM, de Vries LS, Blennow M, Foran A, Shah DK, Livingstone V, van Huffelen AC, Mathieson SR, Pavlidis E, Weeke LC, Toet MC, Finder M, Pinnamaneni RM, Murray DM, Ryan AC, Marnane WP, Boylan GB. Characterisation of neonatal seizures and their treatment using continuous EEG monitoring: a multicentre experience. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 24. pii: fetalneonatal-2018-315624.
O'Sullivan MP, Looney AM, Moloney GM, Finder M, Hallberg B, Clarke G, Boylan GB, Murray DM. Validation of Altered Umbilical Cord Blood MicroRNA Expression in Neonatal Hypoxic-Ischemic Encephalopathy. JAMA Neurol. 2018 Dec 28. doi: 10.1001/jamaneurol.2018.4182.
Soul JS, Pressler R, Allen M, Boylan G, Rabe H, Portman R, Hardy P, Zohar S, Romero K, Tseng B, Bhatt-Mehta V, Hahn C, Denne S, Auvin S, Vinks A, Lantos J, Marlow N, Davis JM; International Neonatal Consortium. Recommendations for the design of therapeutic trials for neonatal seizures. Pediatr Res. 2018 Dec 24. doi: 10.1038/s41390-018-0242-2.
Dempsey EM, Kooi EMW, Boylan G. It's All About the Brain-Neuromonitoring During Newborn Transition. Semin Pediatr Neurol. 2018 Dec;28:48-59. doi: 10.1016/j.spen.2018.05.006.
Finn D, O'Toole JM, Dempsey EM, Boylan GB. EEG for the assessment of neurological function in newborn infants immediately after birth. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 26. pii: fetalneonatal-2018-315231.
O’Shea A, Lightbody G, Boylan G, Temko A. Investigating the Impact of CNN Depth on Neonatal Seizure Detection Performance. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:5862-5865.
Goulding, R. M., Stevenson, N. J., Murray, D. M., Livingstone, V., Filan, P. M., & Boylan, G. B. (2017). Heart rate variability in hypoxic ischemic encephalopathy during therapeutic hypothermia. Pediatr Res. 81(4):609-615.
Ahmed, R., Temko, A., Marnane, W., Lightbody, G., & Boylan, G. (2016). Grading hypoxic–ischemic encephalopathy severity in neonatal EEG using GMM supervectors and the support vector machine. Clinical Neurophysiology, 127(1), 297-309.
Lloyd, R. O., O’Toole, J. M., Livingstone, V., Hutch, W. D., Pavlidis, E., Cronin, A. M., & Boylan, G. B. (2016). Predicting 2-y outcome in preterm infants using early multimodal physiological monitoring. Pediatr Res. 80(3):382-8.
Mathieson, S. R., Stevenson, N. J., Low, E., Marnane, W. P., Rennie, J. M., Temko, A., Lightbody, G., & Boylan, G. B. (2016). Validation of an automated seizure detection algorithm for term
neonates. Clinical Neurophysiology 127(1), 156-168.
Murray, D. M., O’Connor, C. M., Ryan, C. A., Korotchikova, I., & Boylan, G. B. (2016). Early EEG Grade and Outcome at 5 Years After Mild Neonatal Hypoxic Ischemic Encephalopathy. Pediatrics 138(4) Pressler R, Boylan GB, Marlow N et al. (2015). Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurol. 14(5):469-77.
Stevenson NJ, Clancy RR, Vanhatalo S, Rosén I, Rennie JM, Boylan GB. (2015). Interobserver agreement for neonatal seizure detection using multichannel EEG. Ann Clin Transl
Neurol.1;2(11):1002-11.
An Automated System for Grading EEG Abnormality in Term Neonates with Hypoxic-Ischaemic Encephalopathy N. J. Stevenson, I. Korotchikova, A. Temko, G. Lightbody, W. P. Marnane, G. B. Boylan. (2013). Annals of Biomedical Engineering. Volume 41, Issue 4, pp 775-785.
Temko A, Thomas E, Marnane W, Lightbody G, Boylan GB. (2011). Performance assessment for EEG-based neonatal seizure detectors. Clin Neurophysiol. 122(3):474-82.
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