[ISS-L4] Clinical aspects

[L-19] Inborn errors of metabolism in neonatal seizures

Derrick Wei-shih CHAN (KK Women's and Children's Hospital, Singapore)

I am a Senior Consultant and Head of Paediatric Neurology at KK Women’s and Children’s Hospital. I graduated from Nottingham University with Bachelor’s in Medical Science (1996) and Bachelor of Medicine and Surgery (1998), passed my Membership exams for the Royal College of Paediatrics and Child Health in 2002 and obtained Specialist Accreditation in Paediatric Medicine in 2007. I trained in Paediatric EEG at Great Ormond Children’s Hospital in London, UK and the Royal Children’s Hospital in Melbourne, followed by Clinical Fellowship in Paediatric Epilepsy at the Hospital for Sick Children in Toronto. I obtained certification in Clinical Neurophysiology from the Canadian Society of Clinical Neurophysiology in 2008 and received my Master’s Degree in Clinical Investigation in 2011. I set up the comprehensive epilepsy programme at KKH, including the epilepsy monitoring unit, ketogenic diet and complicated epilepsy clinics, vagus nerve stimulator implantation programme and epilepsy surgery programme. I am driving the paediatric epilepsy research programme and have established collaborations in Paediatric Epilepsy with Duke Durham. I have led the Paediatric Neurology team to clinical, research and educational excellence, expanding the team and establishing expertise in vital areas of paediatric neurology. I am an instructor and examiner for the ASEAN Epilepsy Academy (ASEPA) Electro-encephalography exam.

I have research interests in video analytics for seizure detection and HLA-B*1502 alleles in children with carbamazepine hypersensitivity. I am currently PI of NMRC HSRG grant “HSRG-OC17Jun: Cost containment in pharmacogenomic testing, identifying obstacles to implementation of pharmacogenomics and impact on anticonvulsant prescription patterns”. I set up the Paediatric Autoimmune Epilepsy, Demyelination & Encephalitis Study (PAEDES) under the KKH NMRC Centre grant and have conducted translational research in close collaboration with Prof Salvatore Albani and the Singhealth/Duke-NUS Translational Immunology Institute. I am developing the Clinician Innovator track in Singhealth with A/Prof Henry Ho. As Vice-Chair (Research) for the Paediatrics ACP.