[ISS-L6] Treatment 2

[L-27] Umbilical cord blood stem cell therapy for neonatal encephalopathy

Masahiro TSUJI (Kyoto Women's University, Japan)

Professor, Department of Food and Nutrition, Kyoto Women’s University
35 Imakumano, Kitahiyoshi-cho, Higashiyama-ku, Kyoto 605-8501 Japan
E-mail: [e-mail]

Professional Experience
2000-2001 Clinical fellow, Department of Pediatrics,Kobe City General Hospital, Hyogo
2002-2004 Post-doctoral research fellow, Department of Neurology, Kennedy Krieger Institute, Johns Hopkins University, U.S.A
2004-2009 Chief physician, Department of Pediatrics, Kobe City General Hospital, Hyogo
2009-2018 Laboratory Chief, Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center
2018-present Current Positions (See above)

Education
1992 M.D. Faculty of Medicine, Tottori University
2000 Ph.D. (Doctor of Medical Science) Faculty of Medicine, Kyoto University



Recent Publications
1. Tanaka E, Ogawa Y, Mukai T, Sato Y, Hamazaki T, Nagamura-Inoue T, Harada-Shiba M, Shintaku H, Tsuji M. Dose-Dependent effect of intravenous administration of human umbilical cord-derived mesenchymal stem cells in neonatal stroke mice. Front Neurol 9:133, 2018
2. Ohshima M, Taguchi A, Sato Y, Ogawa Y, Saito S, Yamahara K, Ihara M, Harada-Shiba M, Ikeda T, Matsuyama T, Tsuji M. Evaluations of intravenous administration of CD34+ human umbilical cord blood cells in a mouse model of neonatal hypoxic-ischemic encephalopathy. Dev Neurosci 38: 331-341, 2016.
3. Ohshima M, Coq JO, Otani K, Hattori Y, Ogawa Y, Sato Y, Harada-Shiba M, Ihara M. Tsuji M. Mild intrauterine hypoperfusion reproduces neurodevelopmental disorders observed in prematurity. Sci Rep 6: 39377, 2016.
4. Ohshima M, Taguchi A, Tsuda H, Sato Y, Yamahara K, Harada-Shiba M, Miyazato M, Ikeda T, Iida H, Tsuji M. Intraperitoneal and intravenous deliveries are not comparable in terms of drug efficacy and cell distribution in neonatal mice with hypoxia-ischemia. Brain Dev 37: 376-386, 2015.
5. Tsuji M, Taguchi A, Ohshima M, Kasahara Y, Sato Y, Tsuda H, Otani K, Yamahara K, Ihara M, Harada-Shiba M, Ikeda T, Matsuyama T. Effects of intravenous administration of umbilical cord blood CD34+ cells in a mouse model of neonatal stroke. Neuroscience 263: 148-158, 2014.