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How can medications be used to treat substance use disorders, sustain recovery and treat drug overdose?

[FC1-3] Sex differences in the reduction of hopelessness in μ opioid receptor deficient mice by additive effects of δ opioid receptor agonists

*Yuki MORIYA^1,2, Yoshiyuki Kasahara^3,1,4, Masafumi Shimada¹, Yasufumi Sakakibara^1,5, Hideaki Fujii⁶, Hiroshi Nagase⁷, Soichiro Ide², Kazutaka Ikeda², Frank Scott Hall⁸, George R Uhl⁹, Ichiro Sora¹⁰ (1. Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan, 2. Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, 3. Department of Maternal and Fetal Therapeutics, Tohoku University Graduate, School of Medicine, Sendai, Japan , 4. Department of Maternal and Child Healthcare Medical Science, Tohoku, University Graduate School of Medicine, Sendai, Japan, 5. Department of Neurogenetics, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan, 6. Laboratory of Medicinal Chemistry, School of Pharmacy, Kitasato University, Tokyo, Japan , 7. International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan , 8. Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA , 9. Departments of Neurology and Pharmacology, University of Maryland School of Medicine, and VA Maryland Healthcare System, 10. Department of Digital Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan)

Keywords:opiod, stress, antidepressant