Depression 2 - Preclinical (1)

[P107] Prototypic antidepressants act as a G-protein biased LPAR1 agonist and contribute to antidepressant effects

*Naoto KAJITANI^1,2,3, Mami OKADA-TSUCHIOKA³, Asuka INOUE⁴, Kanako MIYANO^5,6, Takeshi MASUDA⁷, Shuken BOKU¹, Kazuya IWAMOTO⁸, Sumio OHTSUKI⁷, Yasuhito UEZONO⁵, Junken AOKI⁹, Minoru TAKEBAYASHI^1,3 (1. Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, 2. Center for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, 3. Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization Kure Medical Center, 4. Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 5. Department of Pain Control Research, The Jikei University School of Medicine, 6. Division of Cancer Pathophysiology, National Cancer Center Research Institute, 7. Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University, 8. Department of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, 9. Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

Keywords:Antidepressant, Lysophosphatidic acid, Biased agonist