Depression 2 - Preclinical (1)

[P109] The causal involvement of the BDNF-TrkB pathway in dentate gyrus in early-life stress-induced cognitive deficits in male mice

*Yaxin Sun¹, Yun-ai Su¹, Qi Wang^1,2, Jiaya Zheng^1,2, Chenchen Zhang^1,2, Ting Wang¹, Xiao Liu¹, Yunu Ma¹, Xuexin Li¹, Xianqiang Zhang¹, Xiaomeng Xie¹, Xiaodong Wang³, Jitao Li¹, Tianmei Si^1,2 (1. Peking University Sixth Hospital, Peking University Institute of Mental Health, Beijing, China, 2. Institute of Mental Health, Wenzhou Medical University, 325035 Wenzhou, China, 3. Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry ofHealth of China, Zhejiang Province Key Laboratory of Neurobiology, Hangzhou, China)

Keywords:Early-life stress, BDNF, TrkB, 7,8-DHF, cognition