Depression 2 - Preclinical (1)

[P119] (R)-ketamine ameliorates depression-like behaviors and cognitive impairment via activation of the anterior insular cortex in social isolation-reared mice

*Rei Yokoyama¹, Yukio Ago², Hisato Igarashi¹, Momoko Higuchi¹, Masato Tanuma¹, Yuto Shimazaki¹, Kaoru Seiriki¹, Misuzu Hayashida¹, Shun Yamaguchi^3,4, Hirokazu Tanaka⁵, Takanobu Nakazawa⁶, Kenji Hashimoto⁷, Atsushi Kasai^1,8, Hitoshi Hashimoto^1,9,10,11,12 (1. Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, 2. Department of Cellular and Molecular Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, 3. Department of Morphological Neuroscience, Graduate School of Medicine, Gifu University, Gifu, Japan, 4. Center for One Medicine Innovative Translational Research, Institute for Advanced Study, Gifu University, Gifu, Japan, 5. Faculty of Information Technology, Tokyo City University, Tokyo, Japan, 6. Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan, 7. Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan, 8. Systems Brain Science Project, Drug Innovation Center, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, 9. Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan, 10. Division of Bioscience, Institute for Datability Science, Osaka University, Osaka, Japan, 11. Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan, 12. Department of Molecular Pharmaceutical Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan)

Keywords:Depression , Ketamine, Social isolation