Epilepsy

[P125] Involvement of PGE2-EP1 signaling in the PTZ-induced epileptic seizure and its neuroinflamation-associated exacerbation

*Yukino Ishizaka¹, Akihiro Mouri^1,5, Kazuo Kunisawa¹, Takaya Nishikawa¹, Tomoyuki Furuyashiki², Shuh Narumiya³, Toshitaka Nabeshima^4,5 (1. Department of Regulatory Science for Evaluation & Development of Pharmaceuticals & Devices, Fujita Health University Graduate School of Health Sciences, Aichi, Japan., 2. Division of Pharmacology, Graduate School of Medicine, Kobe University, Hyogo, Japan., 3. Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., 4. Laboratory of Health and Medical Science Innovation, Fujita Health University Graduate School of Health Science, Aichi, Japan., 5. Japanese Drug Organization of Appropriate Use and Research (J-DO), Aichi, Japan.)

Keywords:epilepsy, neuroinflammation, prostaglandin E2, EP1, cyclooxygenases