Epilepsy

[P128] Development of a physiologically-based pharmacokinetic (PBPK) model to predict plasma and brain exposure following administration of valproic acid and clobazam in combination treatment regimen for Dravet syndrome in children

*Nattapon Jaisupa¹, Michael Ashton¹, Sofia Birgersson¹ (1. Unit for Pharmacokinetic and Drug Metabolism, Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden)

Keywords:valproic acid, clobazam, physiologically-base pharmacokinetic model