Schizophrenia 2 -Preclinical

[P154] Activation of prefrontal parvalbumin interneurons ameliorates working memory deficit even under clinically comparable antipsychotic treatment in a mouse model of schizophrenia

*Yosefu Arime¹, Yoshito Saitoh¹, Yasuo Uchida², Mikiko Ishikawa¹, Chikako Kamiyoshihara¹, Kazuki Fujii^3,4,5, Keizo Takao^3,4,5, Noriaki Ohkawa¹ (1. Division for Memory and Cognitive Function, Research Center for Advanced Medical Science, Comprehensive Research Facilities for Advanced Medical Science, Dokkyo Medical University, 2. Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, 3. Department of Behavioral Physiology, Faculty of Medicine, University of Toyama, 4. Life Science Research Center, University of Toyama, 5. Research Center for Idling Brain Science, University of Toyama)

Keywords:Prelimbic cortex, Parvalbumin, Chemogenetics