Schizophrenia 2 -Preclinical

[P163] Overexpression of vasoactive intestinal peptide receptor 2 in neurons causes abnormal dendritic morphology in the prefrontal cortex and cognitive impairment

*Ami Ono¹, Daichi Koan¹, Satoshi Asano¹, Tatsunori Miyaoka², Lu Chen², Shinsaku Nakagawa², Atsuko Hayata-Takano^3,4, Takanobu Nakazawa⁵, Akihiro Harada⁶, Hitoshi Hashimoto^2,4,6, James A Waschek⁷, Kotaro Tanimoto¹, Yukio Ago¹ (1. Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, 2. Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan, 3. Graduate School of Dentistry, Osaka University, Osaka, Japan, 4. United Graduate School of Child Development, Osaka University, Osaka, Japan, 5. Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan, 6. Graduate School of Medicine, Osaka University, Osaka, Japan, 7. Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, CA, USA)

Keywords:schizophrenia, vasoactive intestinal peptide receptor 2 (VIPR2), cognitive impairment, dendritic morphology, prefrontal cortex (PFC)