Depression 3 - Clinical (2)

[P187] A modeling approach to the therapeutic effect of paroxetine for depression with a focus on pharmacokinetics-pharmacodynamics relationship

*Junji Saruwatari¹, Tomoko Egashira¹, Keiichi Shigetome¹, Tetsu Tomita², Shoko Tsuchimine³, Kazuya Morita¹, Kazuma Iwashita¹, Miki Nishimura¹, Kentaro Oniki¹, Kazutaka Shimoda³, Norio Yasui-Furukori³ (1. Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, 2. Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan, 3. Department of Psychiatry, Dokkyo Medical University School of Medicine, Tochigi, Japan)

Keywords:selective serotonin reuptake inhibitors, modeling & simulation, machine learning