Post-Traumatic Stress Disorders

[P244] (2R,6R)-hydroxynorketamine targeting the basolateral amygdala regulates fear memory

*yuanyuan xu¹, Zhenlong Li², Chau-Shoun Lee^3,4, Hsien-Yu Peng³, Tzer-Bin Lin^5,6,7, Ming-Chun Hsieh³, Cheng-Yuan Lai⁸, Dylan Chou^9,3 (1. Department of Pharmacology, Zhuhai Campus of Zunyi Medical University , 2. School of Basic Medical Sciences, Zhuhai Campus of Zunyi Medical University, 3. Department of Medicine, MacKay Medical College, 4. Department of Psychiatry, MacKay Memorial Hospital, 5. Institute of New Drug Development, College of Medicine, China Medical University, 6. Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, 7. Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, 8. Institute of Biomedical Sciences, MacKay Medical College, 9. Department of Physiology, Zhuhai Campus of Zunyi Medical University)

Keywords:(2R,6R)-hydroxynorketamine , Long-term potentiation, Basolateral amygdala, Synaptic transmission , Fear memory extinction