Schizophrenia 4 - Translational

[P271] Associations between Neuromelanin Accumulation in Patients with Schizophrenia and Treatment Responsiveness: A Cross-Sectional NM-MRI Study

*Fumihiko Ueno^1,2,3, Yusuke Iwata⁹, Shiori Honda³, Guillermo Horga^4,5, Clifford M Cassidy⁶, Edgardo Torres-Carmona^1,7, Jianmeng Song^1,7, Vincenzo de Luca^2,7,8, Sakiko Tsugawa³, Yoshihiro Noda³, Mahavir Agarwal^2,7,8, Philip Gerretsen^1,2,7,8, Shinichiro Nakajima³, Ariel Graff-Guerrero^1,2,7,8 (1. Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada, 2. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada, 3. Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan, 4. Department of Psychiatry, Columbia University, New York, NY, USA, 5. Division of Translational Imaging, New York State Psychiatric Institute, New York, NY, USA, 6. The Royal’s Institute of Mental Health Research Affiliated with the University of Ottawa, Ottawa, Ontario, Canada, 7. Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, 8. Campbell Family Mental Health Research Institute, CAMH, Toronto, Ontario, Canada, 9. Department of Neuropsychiatry, University of Yamanashi, Faculty of Medicine, Yamanashi, Japan)

キーワード：Neuromelanin, Dopamine, Schizophrenia, Substantia nigra, Clozapine