Sleep Disorders

[P299] Chronic sleep fragmentation accelerates the development of prodromal symptoms and pathological changes in Parkinson’s disease model mice

*Masayuki Miyazaki^1,2, Hiroko Yagihara¹, Hiromi Fujita³, Hodaka Yamakado⁴, Keiji Wada³, Eiko N Minakawa¹ (1. Department of Neurophysiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan, 2. Department of NCNP Brain Physiology and Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, 3. Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan, 4. Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan)

Keywords:Parkinson’s disease, Insomnia, Prodromal phase