Autism

[P318] α6GABA_A receptor-selective positive allosteric modulator as a potential novel therapy for autism: A preclinical study in offspring of valproic acid-treated rats

*Yi-Ting Pan¹, Chi-Chun Wu³, Ming-Chai Chu³, Chen-Jiun Yeh¹, Dishary Sharmin⁴, James Cook⁴, Hui-Ching Lin³, Lih-Chu Chiou^1,2 (1. Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan, 2. Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan, 3. Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, 4. Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA)

Keywords:Autism spectrum disorder, Cerebellar–prefrontal cortical circuits, E/I imbalance, α6GABAARs PAM