Preclinical - Others (1)

[P344] KNT-127, a delta opioid receptor agonist, ameliorates psychological stress-induced irritable bowel syndrome-like symptoms through the central nervous system

*Toshinori Yoshioka¹, Daisuke Yamada¹, Mayuna Yamazaki¹, Takumi Hamano¹, Sayaka Kimiki¹, Hiroshi Nagase², Akiyoshi Saitoh¹ (1. Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan, 2. University of Tsukuba, Ibaraki, Japan)

Keywords:psychological stress, gut–brain axis, irritable bowel syndrome, delta opioid receptor, insular cortex