Dementia 2 - Preclinical and others

[P385] Cathepsin B play a critical role in Amyloid β influx via cerebral endothelial cells during Porphyromonas gingivalis infection

*Shuge Gui¹, Fan Zeng², Yicong Liu^3,4, Junjun Ni⁵, Zhou Wu^6,7 (1. Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka, Japan, 2. Shenzhen Key Laboratory of Immunomodulation for Neurological Diseases, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 3. The Affiliated Stomatology Hospital, School of Medical, Zhejiang University, Zhejiang, China, 4. Key Laboratory of Oral Biomedical Research of Zhejiang Province, School of Stomatology, Zhejiang University, Zhejiang, China, 5. Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing,China, 6. Department of Aging Science and Pharmacology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan, 7. OBT Research Center, Faculty of Dental Science, Kyushu University, Fukuoka, Japan)

Keywords:Cathepsin B, RAGE, cerebral endothelial cells