Depression 5 - Clinical (3)

[P430] Effect modification of tumor necrosis factor-α on the kynurenine and serotonin pathways in major depressive disorder on type 2 diabetes mellitus

*Naomichi Okamoto¹, Takashi Hoshikawa¹, Yuichi Honma², Enkhmurun Chibaatar¹, Atsuko Ikenouchi^1,3, Masaru Harada², Reiji Yoshimura¹ (1. Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, Japan, 2. Third Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, Japan, 3. Medical Center for Dementia, University Hospital, University of Occupational and Environmental Health, Fukuoka, Japan)

Keywords:major depressive disorder, kynurenine pathway, tryptophan metabolism , quinolinic acid, tumor necrosis factor-α