Depression 6 - Translational

[P452] Difference in treatment-response of iPSC-derived neurons to Reelin and (2R,6R)-HNK from participants with treatment-resistant depression

*Jenessa Johnston¹, Brandi Quintanilla^1,2, Peixiong Yuan¹, Shiyong Peng¹, Mani Yavi¹, Hector Caruncho³, Bashkim Kadriu^1,4, Carlos Zarate Jr. ¹ (1. National Institute of Mental Health, 2. UT Health Houston, 3. University of Victoria, 4. Jazz Pharmaceuticals)

Keywords:Induced pluripotent stem cells, Treatment-resistant depression, Ketamine, (2R,6R)-HNK, Reelin