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[P461] BTRX-246040 Acts Through the Ventrolateral Periaqueductal Gray to Exert Antidepressant-Relevant Actions in Mice

*Zhenlong Li¹, Yuanyuan Xu², Rourou Li¹, Zhenyu Sheng¹, Xueman Liu¹, Chau-Shoun Lee³, Hsien-Yu Peng³, Tzer-Bin Lin⁶, Ming-Chun Hsieh³, Cheng-Yuan Lai⁴, Han-Fang Wu⁵, Dylan Chou³ (1. School of Basic Medical Sciences,Zhuhai Campus of Zunyi Medical University,Zhuhai, Guangdong,China, 2. Department of Pharmacology,Zhuhai Campus of Zunyi Medical University,Zhuhai, Guangdong,China, 3. Department of Medicine, MacKay Medical College, New Taipei, Taiwan, 4. Institute of Biomedical Sciences,MacKay Medical College,New Taipei,Taiwan, 5. Department of Optometry, MacKay Medical College, New Taipei, Taiwan, 6. Institute of New Drug Development, College of Medicine, China Medical University, Taichung, Taiwan)

Keywords:BTRX-246040, antidepressant, glutamatergic transmission, ventrolateral periaqueductal gray, learned helplessness