Childhood & Adolescent Disorders

[P489] Proline-rich transmembrane protein 2 knock-in mice present nigrostriatal dopaminergic hyperactivity and increased susceptibility to L-dopa-induced motor deficits

*Daisuke Hatta¹, Kaito Kanamoto¹, Shiho Makiya¹, Kaori Watanabe¹, Tatsuya Kishino^2,5, Yuki Fuchigami³, Shigeru Kawakami³, Akira Kinoshita^4,5, Koh-ichiro Yoshiura^4,5, Naohiro Kurotaki⁴, Keiro Shirotani^1,5, Nobuhisa Iwata^1,5 (1. Department of Genome-based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 2. Division of Functional Genomics, Research Center for Advanced Genomics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 3. Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 4. Department of Human Genetics, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 5. Leading Medical Research Core Unit, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan)

Keywords:PRRT2, paroxysmal kinesigenic dyskinesia, dopamine, striatum, L-dopa