The 35th CINP World Congress of Neuropsychopharmacology

Presentation information

[CINP2024] Poster Session

CINP2024 » Poster Session

Childhood & Adolescent Disorders

Sun. May 26, 2024 1:30 PM - 2:30 PM CINP Poster Session Hall (Lobby Gallery)

[P489] Proline-rich transmembrane protein 2 knock-in mice present nigrostriatal dopaminergic hyperactivity and increased susceptibility to L-dopa-induced motor deficits

*Daisuke Hatta1, Kaito Kanamoto1, Shiho Makiya1, Kaori Watanabe1, Tatsuya Kishino2,5, Yuki Fuchigami3, Shigeru Kawakami3, Akira Kinoshita4,5, Koh-ichiro Yoshiura4,5, Naohiro Kurotaki4, Keiro Shirotani1,5, Nobuhisa Iwata1,5 (1. Department of Genome-based Drug Discovery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 2. Division of Functional Genomics, Research Center for Advanced Genomics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 3. Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 4. Department of Human Genetics, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 5. Leading Medical Research Core Unit, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan)

Keywords:PRRT2, paroxysmal kinesigenic dyskinesia, dopamine, striatum, L-dopa

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