Schizophrenia 5 - Clinical (3)

[P504] A retrospective comparative study of clinical response to clozapine between patients with early treatment-resistant schizophrenia (TRS) and late TRS

*Nobuhisa Kanahara^1,13, Kazuki Okada², Yuji Otsuka³, Remiko Kobayashi², Hiroshi Kimura⁴, Hiroshi Yamanaka⁵, Yuri Takaoki⁶, Taisuke Yoshida⁷, Takahiro Oiwa⁸, Fumiaki Ito⁹, Hiroshi Komatsu¹⁰, Takashi Ono¹¹, Yuki Kikuchi¹², Takahisa Saiga⁶, Shingo Noda¹³, Masaomi Iyo² (1. Chiba University Center for Forensic Mental Health, Chiba, Japan, 2. Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan, 3. Department of Psychiatry, Asahi General Hospital, Asahi, Japan, 4. Department of Psychiatry, Gakuji-kai Kimura Hospital, Chiba, Japan, 5. Department of Psychiatry, Chiba Psychiatric Medical Center, Chiba, Japan, 6. Department of Psychiatry, Japanese Red Cross Narita Hospital, Narita, Japan, 7. Department of Psychiatry, Doujin-kai Kisarazu Hospital, Kisarazu, Japan, 8. Department of Psychiatry, Naoki-kai Isogaya Hospital, Ichihara, Japan, 9. Department of Psychiatry, National Hospital Organization Hanamaki Hospital, Hanamaki, Japan, 10. Department of Psychiatry, Tohoku University Hospital, Sendai, Japan, 11. Department of Psychiatry, Miyagi Psychiatric Center, Natori, Japan, 12. Department of Psychiatry, Yukou-kai, Kodama Hospital, Ishinomaki, Japan, 13. Department of Psychiatry, Ichihara-Tsuruoka Hospital, Ichihara, Japan)

Keywords:Treatment-resistant schizophrenia, Clozapine, Antipsychotic, Dopamine supersensitivity, Treatment response