[SS5-3] APOE, DRD3, BDNF, and COMT Polymorphisms in Relation to BPSD in a Philippine Population
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Presentation information
[CINP2024] Spotlight Session
CINP2024 » Spotlight Session
Spotlight Session 5
Into a Culture Specific Perspective of Dementia Care in the Philippines: A Joint Symposium of the Philippine Psychiatric Association and Philippine College of Psychopharmacology
Fri. May 24, 2024 3:00 PM - 4:00 PM Room 5 (G409)
Chair: Robert D. Buenaventura (Department of Psychiatry, University of the East Ramon Magsaysay Memorial Medical Center Inc., Quezon City, Philippines)
Abstract:
The global rise in the elderly population, particularly those with dementia, underscores the urgency of addressing the associated challenges. In the Philippines, dementia prevalence among older adults is higher than the regional average, emphasizing the need for effective screening tools. Undetected dementia rates vary globally, necessitating locally validated tools like MMSE-P and MoCA-P. Concurrently, raising awareness about dementia is crucial for early detection.
Further, the complex nature of behavioral and psychological symptoms of dementia (BPSD) requires exploration, considering gene interactions, gender-specific effects, and diverse environmental influences. A study on a Filipino population explored associations between APOE, DRD3, BDNF, and COMT polymorphisms and BPSD endophenotypes, revealing significant associations with APOE, DRD3, and COMT minor alleles. Ethnic variations in genetic risk for BPSD underscore the complex interplay of genetics and environment.
The evolving landscape of Alzheimer's Disease (AD) diagnosis and management involves biomarkers for precise detection, enhancing diagnostic accuracy crucial for emerging disease-modifying therapies. Symptomatic therapies persist, but the promise of slowing AD progression is evident with disease-modifying therapy. The multimodal approach to dementia prevention, considering risk factors and early detection, is paramount. An innovative component incorporated in this intervention is INDAK, which captures the unique culture of Filipinos.