[1P-0061（1AT26-12）] The additional deletion of Engase can partially rescue the defects caused by Ngly1 deletion

〇Haruhiko Fujihira^1,2, Yuki Negishi-Masahara¹, Masaru Tamura³, Daisuke Takakura^4,5, Chengcheng Huang¹, Shigeharu Wakana³, Nana Kawasaki⁴, Yoko Funakoshi¹, Tadashi Suzuki¹ (1.Glycometabolome Team, Global Research Cluster, RIKEN, 2.Div. of Glycobiologics, Intractable Dis. Res. Center, Juntendo Univ. Graduate Sch. of Med., 3.Technol. and Devel. Team for Mouse Phenotype Anal., BRC, RIKEN, 4.Lab. of Biopharmaceut. and Regenerative, Graduate Sch. of Med. Life, Yokohama City Univ., 5.Center for Integrated Med. Res., Keio Univ.)

Peptide:N-glycanase (Ngly1)、Endo-beta-N-acetylglucosaminidase (ENGase)、NGLY1-deficiency、protein degradation system