Synthesis of saxitoxin derivatives focusing on the C11 position and evaluation of their inhibitory activity towards sodium channel with whole-cell-patch-clamp recordings

○HOSHI

Presentation information

Academic Program (AP) [Poster]

Natural Products Chemistry

Mon. Mar 18, 2019 10:00 AM - 11:30 AM P (Arena, Gymnasium and Auditorium [1F])

Presentation time：Odd Poster Number 10:00-10:45 / Even Poster Number 10:45-11:30

[3PA-056] Synthesis of saxitoxin derivatives focusing on the C11 position and evaluation of their inhibitory activity towards sodium channel with whole-cell-patch-clamp recordings

Poster

○HOSHI, Minami; ADACHI, Kanna; YAMADA, Satoshi; OKI, Mana; ISHIZUKA, Hayate; KONOKI, Keiichi; YOTSU-YAMASHITA, Mari; NAGASAWA, Kazuo (Fac. Eng., Tokyo Univ. of Agri. and Technol.)

Keywords:voltage-gated sodium channel、saxitoxin、11-saxitoxinethanoic acid、guanidine alkaloid、Mukaiyama aldol reaction

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