IATDMCT 2017

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[O27-2] O27-2: Pharmacometrics (2)

Wed. Sep 27, 2017 11:15 AM - 12:00 PM Room C1 (1F)

Chairs: Fumiyoshi Yamashita, Japan / Toshimi Kimura, Japan

[O27-2-3] Model-informed precision dosing of sirolimus in children with vascular anomalies: pharmacokinetic-guided dose adjustment and design of age-appropriate starting dosing regimens

Tomoyuki Mizuno1, Chie Emoto2, Tsuyoshi Fukuda3, Paula S. Mobberley-Schuman4, Adrienne M. Hammill5, Denise M. Adams6, Alexander A. Vinks7 (1.Cincinnati Children's Hospital Medical Center, 2.Cincinnati Children's Hospital Medical Center, 3.Cincinnati Children's Hospital Medical Center, 4.Cincinnati Children's Hospital Medical Center, 5.Cincinnati Children's Hospital Medical Center, 6.Cincinnati Children's Hospital Medical Center, 7.Cincinnati Children's Hospital Medical Center)

Keywords:Model-informed precision dosing, Bayesian adaptive control, Pediatrics, Neonates and infants, mTOR inhibitor

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