[O27-2] O27-2: Pharmacometrics (2)

[O27-2-3] Model-informed precision dosing of sirolimus in children with vascular anomalies: pharmacokinetic-guided dose adjustment and design of age-appropriate starting dosing regimens

Tomoyuki Mizuno¹, Chie Emoto², Tsuyoshi Fukuda³, Paula S. Mobberley-Schuman⁴, Adrienne M. Hammill⁵, Denise M. Adams⁶, Alexander A. Vinks⁷ (1.Cincinnati Children's Hospital Medical Center, 2.Cincinnati Children's Hospital Medical Center, 3.Cincinnati Children's Hospital Medical Center, 4.Cincinnati Children's Hospital Medical Center, 5.Cincinnati Children's Hospital Medical Center, 6.Cincinnati Children's Hospital Medical Center, 7.Cincinnati Children's Hospital Medical Center)

キーワード：Model-informed precision dosing, Bayesian adaptive control, Pediatrics, Neonates and infants, mTOR inhibitor