[O27-4] O27-4: Oncology (2)

[O27-4-3] The effects of advanced age and serum alpha1-acid glycoprotein on Docetaxel unbound exposure and dose-limiting toxicity in cancer patients

Hirotsugu Kenmotsu¹, Chiyo K. Imamura², Akira Ono³, Shota Omori⁴, Kazuhisa Nakashima⁵, Kazushige Wakuda⁶, Tetsuhiko Taira⁷, Tateaki Naito⁸, Murakami Haruyasu⁹, Takahashi Toshiaki¹⁰, Yusuke Tanigawara¹¹ (1.Shizuoka Cancer Center, 2.Keio University School of Medicine, 3.Shizuoka Cancer Center, 4.Shizuoka Cancer Center, 5.Shizuoka Cancer Center, 6.Shizuoka Cancer Center, 7.Shizuoka Cancer Center, 8.Shizuoka Cancer Center, 9.Shizuoka Cancer Center, 10.Shizuoka Cancer Center, 11.Keio University School of Medicine)

キーワード：alpha1-acid glycoprotein, age, docetaxel, neutropenia, unbound exposure