[P26-3] P26-3: Central nervous system drugs (2)

[P26-3-8] Influence of the cytochrome P450 2D6 polymorphisms on the pharmacokinetics of paroxetine in Japanese patients with major depressive disorder: a population pharmacokinetic analysis

Kazuma Iwashita¹, Junji Saruwatari², Mikito Ueda³, Miki Nishimura⁴, Akiko Aoki⁵, Shoko Tsuchimine⁶, Kentaro Oniki⁷, Kazutaka Shimoda⁸, Norio Yasui-Furukori⁹ (1.Kumamoto University, 2.Kumamoto University, 3.Dokkyo Medical University, 4.Kumamoto University, 5.Dokkyo Medical University, 6.Hirosaki University, 7.Kumamoto University, 8.Dokkyo Medical University, 9.Hirosaki University)

Keywords:paroxetine, genetic polymorphisms, cytochrome P450, population pharmacokinetics, dose requirement