High exposure to fludarabine in conditioning prior to allogeneic hematopoietic cell transplantation predicts impaired CD4 reconstitution and lower probability of survival

Erik van Maarseveen

[P26-7-10] High exposure to fludarabine in conditioning prior to allogeneic hematopoietic cell transplantation predicts impaired CD4 reconstitution and lower probability of survival

Erik van Maarseveen¹, Jurgen Langenhorst², Charlotte van Kesteren³, Thomas Dorlo⁴, Stefan Nierkens⁵, Jurgen Kuball⁶, Moniek de Witte⁷, Alwin Huitema⁸, JaapJan Boelens⁹ (1.University Medical Center Utrecht, 2.University Medical Center Utrecht, 3.University Medical Center Utrecht, 4.Antoni van Leeuwenhoek Hospital/Netherlands Cancer Institute
, 5.University Medical Center Utrecht, 6.University Medical Center Utrecht, 7.University Medical Center Utrecht, 8.University Medical Center Utrecht, Antoni van Leeuwenhoek Hospital/Netherlands Cancer Institute, 9.University Medical Center Utrecht)

Keywords:Fludarabine exposure, CD4+ T-cell reconstitution, Overall survival

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Presentation information

[P26-7] P26-7: Oncologic drugs (3): Pharmaometrics, PK/PD, special population

[P26-7-10] High exposure to fludarabine in conditioning prior to allogeneic hematopoietic cell transplantation predicts impaired CD4 reconstitution and lower probability of survival

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