[P26-7] P26-7: Oncologic drugs (3): Pharmaometrics, PK/PD, special population

[P26-7-2] Mechanism-based pharmacokinetics and pharmacodynamics neutropenia model for irinotecan hydrochloride considering UGT1A1 genotyping

Takumi Maruyama¹, Yukihiro Hamada², Yutaka Fukaya³, Satoshi Yamazaki⁴, Yujiro Geka⁵, Kazuhiko Hayashi⁶, Toshimi Kimura⁷ (1.Tokyo Women's Medical University Hospital, 2.Tokyo Women's Medical University Hospital, 3.Tokyo Women's Medical University Hospital, 4.Tokyo Women's Medical University Hospital, 5.Tokyo Women's Medical University Hospital, 6.Tokyo Women's Medical University Hospital, 7.Tokyo Women's Medical University Hospital)

Keywords:irinotecan hydrochloride, UGT1A1 genotyping, Mechanism-based PK/PD, neutropenia model