[S-10] S-10: Progress of TDM for hematopoietic stem cell transplantation

[S-10-5] Pharmacokinetically-guided dosing of melphalan in children undergoing hematopoietic stem cell transplantation: a test dose approach using sparse optimal sampling

Kana Mizuno¹, Sharat Chandra², Tsuyoshi Fukuda³, Junfang Zhao⁴, Ashley Teusink-Cross⁵, Stella M. Davies⁶, Rebecca A. Marsh⁷, M. Christa Krupski⁸, Kenneth Setchell⁹, ParindaA Mehta¹⁰, Alexander A. Vinks¹¹ (1.Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, 2.Cincinnati Children's Hospital Medical Center, 3.Cincinnati Children's Hospital Medical Center, 4.Cincinnati Children's Hospital Medical Center, 5.Cincinnati Children's Hospital Medical Center, 6.Cincinnati Children's Hospital Medical Center, 7.Cincinnati Children's Hospital Medical Center, 8.Cincinnati Children's Hospital Medical Center, 9.Cincinnati Children's Hospital Medical Center, 10.Cincinnati Children's Hospital Medical Center, 11.Cincinnati Children's Hospital Medical Center)

Keywords:melphalan, individualization, Bayesian estimation, optimal sampling stratgy, children