Session information

Session

[Session 7] P450-Dependent Drug Metabolism

Sun. Jun 14, 2015 9:00 AM - 11:00 AM Hall A (International Conference Room 1F)

Chair:Yoichi Naritomi (Astellas Pharma Inc.)

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[Session 7-1] Mitigating Idiosyncratic Toxicity Risks with the N1-substituted-6-arylthiouracils Class of Myeloperoxidase Inactivators: Identification of a Clinical Candidate to Treat Cardiovascular Diseases

^○Amit Kalgutkar (Pharmacokinetics, Dynamics and Metabolism Department, Pfizer Inc.)

[Session 7-2] CYTOCHROME 450 ENZYMES IN THE HUNT FOR ACTIVE METABOLITES

^○R. Scott Obach (Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Pfizer Inc.)

[Session 7-3] Utility of iPS Cells for Study of Drug Metabolism and Pharmacokinetics: Differentiation of human iPS cells into hepatocytes and enterocytes

^○Tamihide Matsunaga (Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University)

[Session 7-4] The use of xenobiotic receptor and P450 humanized mice in elucidating the mechanisms of drug-induced toxicity

^○Frank J. Gonzalez ¹, Jie Cheng ¹, Xiaochao Ma ¹ (1.Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, 3.Department of Pharmaceutical Sciences, University of Pittsburgh)

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