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[Session 9] Drug Protein Binding and Idiosyncratic Drug Reactions

Sun. Jun 14, 2015 1:50 PM - 3:50 PM Hall A (International Conference Room 1F)

Chair:Jack Uetrecht (Pharmaceutical Sciences, University of Toronto), Chair:Raku Shinkyo (Eisai Co., Ltd.)

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[Session 9-1] How do reactive metabolites lead to the immune response that can lead to an idiosyncratic drug reaction?

^○Jack Uetrecht (Pharmaceutical Sciences, University of Toronto)

[Session 9-2] The role of drug and drug metabolite-specific T-cells in immunological drugs reactions targeting liver and skin

^○Dean J. Naisbitt (MRC Centre for Drug Safety Science, the Department of Molecular and Clinical Pharmacology, The University of Liverpool)

[Session 9-3] Integrating metabolic bioactivation alongside other adverse properties to predict and avoid human adverse drug reactions

^○Gerry Kenna (FRAME Office, FRAME)

[Session 9-4] Risk Assessment of Chemically Reactive Metabolites and Idiosyncratic Drug Toxicity in Drug Discovery and Development

^○Hideo Takakusa (Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd)