*Shun Ishigaki¹, Shiho Suzuki¹, Keita Saku², Toshikatsu Washio³, Yoshiaki Yamagishi⁴, Masuo Kondoh⁵, Tatsuhiko Arafune¹ (1. Graduate School of Science and Engineering, Tokyo Denki University, 2. National Cerebral and Cardiovascular Center, 3. National Institute of Advanced Industrial Science and Technology, 4. Osaka University Hospital, 5. Graduate School of Pharmaceutical, Osaka University)