[P1-2-32] Varying effects of periodontal pathogens on both the growth and virulence factors of general pathogens
Keywords:微生物、その他、細菌
Periodontal disease is caused by an increase in the number of periodontal pathogens in the gingival sulcus due to inadequate oral care and other factors, and is associated with the development of not only oral diseases but also systemic diseases. In this regard, the increase in periodontal pathogens may also affect general pathogens. Here, we investigated on whether the culture supernatants of periodontal pathogens effect both the growth and virulence factors of general pathogens found in the oral cavity. The culture supernatants of five periodontal pathogens were used as samples, and both Streptococcus pneumoniae and Candida albicans were used as representative general pathogens. Effects on growth were examined by nephelometry. The effects on virulence factors were examined for hemolytic activity in S. pneumoniae and both adhesive and biofilm-forming activities in C. albicans. The presence of periodontal pathogenic culture supernatants into the culture medium for each species, the Tannerella forsythia culture supernatants showed a tendency to promote the growth of both species. Moreover, the hemolytic activity of S. pneumoniae was increased in the Fusobacteirum nucleatum supernatant. Additionally, both the adhesive and biofilm-forming activities of C. albicans tend to be enhanced in the Porphyromonas gingivalis, F. nucleatum, and T. forsythia culture supernatants. Overall, these results suggest that culture supernatants of periodontal pathogens affect the growth and virulence factors of both S. pneumoniae and C. albicans.