Poster session

[P1-2-36] The proliferation mechanism of odontogenic epithelial cells involving in the pathogenesis of radicular cysts

〇Ryoko Nagano^1,2, Shinsuke Fujii^1,3, Tamotsu Kiyoshima¹ (1. Sect Oral Pathol, Kyushu Univ Grad Sch Dent, 2. Sect Endodont Oper Dent, Kyushu Univ Grad Sch Dent, 3. DDR ctr, Kyushu Univ Grad Sch Dent)

Keywords:上皮組織、炎症、シグナル伝達

Radicular cyst is the most common cyst of the jaws and develops following apical periodontitis. The lining epithelium is derived from the proliferation of odontogenic epithelial cell rests of Malassez (ERMs). ERMs are maintained at a lower proliferative state under physiological conditions, but the regulatory mechanisms underlying inflammation-dependent enhanced-proliferative capabilities of ERMs are not fully understood. Herein, we demonstrated the role of the relationship between TGF-β-Smad2 signaling and IL-1β-p65 signaling in the regulation of odontogenic epithelial cell proliferation using pathological specimens and cell lines. Based on immunofluorescence and immunohistochemical analyses, as well as the results of co-culture experiments with odontogenic epithelial cells and periodontal ligament-derived cells, it was suggested that IL-1β-p65 signaling promotes odontogenic epithelial cell proliferation through suppressing TGF-β-Smad2 signaling in the pathogenesis of radicular cysts.