[P1-2-45] Local administration of quercetin inhibits the hyperexcitability of nociceptive trigeminal ganglion neurons innervating inflamed tissues
Keywords:ケルセチン、局所麻酔効果、三叉神経節ニューロン
The aim of the present study was to examine whether local administration of quercetin into the inflamed tissues attenuates the excitability of nociceptive TG neurons in response to mechanical stimulation. The mechanical escape threshold was significantly lower in inflamed day 1 rats compared to before CFA injection. Extracellular single unit recordings were made from TG neurons of CFA-induced inflammation in anesthetized rats in response to orofacial mechanical stimulation. The mean firing frequency of TG neurons in response to nociceptive mechanical stimulation was reversibly inhibited by 1mM quercetin. The mean firing frequency of inflamed TG neurons in response to mechanical stimuli was reversibly inhibited by 1% lidocaine. The mean magnitude of inhibition on TG neuronal discharge frequency with 1mM quercetin was significantly larger than that of the local anesthetic, 1% lidocaine.These results suggest that local injection of quercetin into the inflamed tissues suppresses the excitability of nociceptive primary sensory neurons in the TG, thus our findings contribute to the area of complementary and alternative medicines.
Conflict of Interest: The authors declare no conflict of interest.
Conflict of Interest: The authors declare no conflict of interest.