[P1-3-05] Mechanisms of diversification of the bat palate and formation of cleft palate-like morphology.
Keywords:口蓋形成、進化発生学、コウモリ
Bats, which account for 20% of mammalian species, are known for their remarkably diversified craniofacial morphology through their diverse diet and echolocation abilities. It is particularly noteworthy from a dentistry point of view that human cleft palate-like morphology is found naturally in some bat lineages. However, no attempt has been made to address this issue from the perspective of dentistry. Furthermore, due to the rarity of the embryos, developmental studies have yet to progress much, and there have been few reports on the morphogenetic mechanisms of the craniofacial region. Therefore, we aim to elucidate the diversification mechanism of the bat palate through comparative developmental studies using bat embryos. We aim to elucidate the molecular mechanisms that give rise to diverse morphologies and to provide insight into the mechanistic mechanisms underlying the development of cleft lip and palate in humans from an entirely new perspective. We are currently focusing on the more rostral bones of the palate, the premaxilla, and the palatine process of the maxilla. We are studying two bat species with different cleft-like morphologies (Vespertilo sinensis, Rhinolophus cornutus) and one with no cleft (Cynopterus sphinx). In this presentation, we will report on comparing the expression sites of osteogenic signals and cell proliferation markers in the planned site of the premaxilla and maxillary bone formation between the three species, as well as the morphological changes chronologically.