Poster session

[P2-2-32] Analysis of neuroimmunological influence on brain by oral infectious disease

〇Sari Kishikawa^1,2, Jun-ichi Nagao^1,2, Kenji Toyonaga^1,2, Emi Kaji¹, Masanobu Nakagami¹, Aoba Iwanuma¹, Sonoko Tasaki¹, Kanae Negoro^1,2, Yoshihiko Tanaka^1,2 (1. Div Infect Biol, Fukuoka Dent Coll, 2. Oral Med Res Ctr, Fukuoka Dent Coll)

Keywords:感染、免疫、Porphyromonas gingivalis

Periodontitis is the chronic oral infectious disease caused by periodontal bacteria. It is the most cause among the diseases of tooth loss and is the infectious diseases that exists in a wide range of generations from young to old. In the long time, periodontal disease has been reported to be various risk factors for systemic disorders. Recently, it has been cleared that older people with severe periodontal disease are at higher risk of dementia than unaffected patients, and people with dementia may develop mental disorders such as anxiety and depression before the onset of dementia. Some immune cells have been reported to be involved in the development of psychiatric disorders. However, the neuroimmunological risk of periodontal disease to the adolescent brain remains unclear. In this study, we developed a mouse model of periodontal disease by infection of periodontal bacteria Porphyromonas gingivalis. We focused on the behavioral changes using the mouse model of periodontal disease and analyzed that neuroimmunological influence of P. gingivalis infection on the brain of young mice.