[P2-3-11] Effects of dopamine receptor antagonist injection into the striatum on the swallowing reflex
Keywords:線条体、ドパミン受容体拮抗薬、嚥下反射
The aim of this study was to investigate whether injection of dopamine receptor antagonist into the striatum modulate on the swallowing reflex. These experiments were performed on rats anesthetized by urethane (1.3 g/kg, i. p.). The swallowing reflex was evoked by electrical stimulation (0.2 ms duration, 30 Hz, 10 s) of the superior laryngeal nerve. Electromyograms were recorded from the mylohyoid muscle to identify swallowing reflex. The dopamine D1 receptor antagonist Sch-23390 (5 μg / μl) or the D2 receptor antagonist domperidone (5 μg / μl) were injected (2 μl, 90 seconds) into the central part of the striatum. The number of swallows was not changed after injection of Sch-23390. The number of swallows was significantly reduced from 10 to 25 min after injection of domperidone. These results suggested that the indirect pathway of the basal ganglia may be involved in control of the swallowing reflex. Conflict of Interest: The author declares no conflict of interests.