Poster session

[P2-3-27] Elucidation of the role of intestinal microbiome in controlling the pathogenesis of periodontitis

〇Masanobu Nakagami^1,2, Jun-ichi Nagao^1,3, Sari Kishikawa^1,3, Kenji Toyonaga^1,3, Emi Kaji¹, Aoba Iwanuma¹, Yasunori Yoshinaga^2,3, Ryuji Sakagami², Yoshihiko Tanaka^1,3 (1. Div infact Biol, Fukuoka Dent Coll, 2. Div Periodontol, Fukuoka Dent Coll, 3. Oral Med Res Ctr, Fukuoka Dent Coll)

Keywords:微生物、獲得免疫、細菌

Periodontitis is one of the two major oral diseases. In Japan, the number of patients with periodontitis is increasing and is of great social concern. Periodontitis is known to be caused by periodontal pathogenic bacteria in the oral cavity. Recent reports have revealed that the pathogenesis of periodontitis, which promotes inflammation of periodontal tissues and alveolar bone resorption, plays an important role in host immune responses, especially Th17 cells producing the cytokine IL-17A. Our group has recently reported that the development of periodontitis is mediated by a systemic immune response of Th17 cells via the intestinal mucosal immune system. Furthermore, we also found that the systemic Th17 cell response is regulated by the intestinal microbiome. However, the role of intestinal microbiome in the development of periodontal disease remains poorly understood. Intestinal microbiome has been reported to produce a variety of metabolites in the intestinal tract, thereby exerting various effects on the host's immune response. We hypothesized that the differentiation of Th17 cells involved in the development of periodontitis may be regulated by intestinal microbiome. In this study, we focus on intestinal microbiome and their metabolites to analyze their effects on Th17 cell differentiation and the development of periodontitis.