SL

[SL3-01] The new vaccine science and design

Ken J. ISHII
(Professor, Division of Vaccine Science, The Institute of Medical Science, The University of Tokyo)

The year 2020 will go down in history as the year in which two revolutions in vaccine development research occurred as a result of the COVID-19 pandemic, with a new type of vaccine that had never existed before becoming available in approximately 300 days. The first was the emergence of a new type of vaccine called mRNA, and the second was a revolution in vaccine clinical trial methods. In Japan, the development of domestically produced vaccines was delayed and was ridiculed as "vaccine defeat," but domestic vaccines are finally being put to practical use by 2023. In the meantime, I would like to offer some of the events I have seen and heard about, as well as topics related to vaccines that will occur in the near future. In particular, I would like to discuss next-generation modalities such as vaccines made of DNA and RNA, lipid nanoparticles, development of adjuvants, their immunological mechanisms of action, relationship with adverse reactions, and future developments.
COI;Collaboration with Daiichisankyo, Shionogi, KMB, Torii Pharma, Zeria Pharma, Exorphia
Lab HP; https://vaccine-science.ims.u-tokyo.ac.jp